Tranexamic acid in knee arthroplasty: the effect of preoperative intravenous administration of together with postoperative intravenous maintenance and periarticular administration on bleeding, transfusion, and hospitalization time – a retrospective cohort study

Objective: To compare patients who received preoperative intravenous (IV) plus postoperative maintenance IV tranexamic acid (TXA) therapy and perioperative periarticular TXA to those did not receive during total knee arthroplasty (TKA) in terms of blood loss, transfusion requirements, length hospital stay.
 Material Method: Data from 194 underwent TKA between 2016 2019 were reviewed. A 106 included. Twenty-one male, 95 female. The divided into three groups: Group 1 (n=37) that TXA, 2 (n=35) therapy, 3 (n=34) TXA. groups similar regarding demographic data. Statistical comparisons the made concerning decrease hemoglobin levels on days 3, need for transfusion, Results: mean first third 1.69(±1.13) 2.94(±1.14)g/dl, 1, 1.41(±0.99) 2.44(±1.28)g/dl, 2, 1.24(±0.83) 2.21(±0.84)g/dl respectively. statistical comparison revealed a significant difference Groups day(p